Clot stability as a determinant of effective factor VIII replacement in hemophilia A

Detection of Factor VIII Inhibitors in Hemophilia A Patients

Background: Factor VIII administration to hemophilia A patients results in an immune response (inhibitor formation) which significantly complicates the therapy. The present study was performed to determine the prevalence of inhibitor development in hemophilia A patients receiving recombinant factor VIII therapy. Materials and Methods: This was an observational descriptive study. Clotting fac...

Coagulation Therapy in Hemophilia A and its Relation to Factor VIII Inhibitor in Northeast of Iran

detection of factor viii inhibitors in hemophilia a patients

background: factor viii administration to hemophilia a patients results in an immune response (inhibitor formation) which significantly complicates the therapy. the present study was performed to determine the prevalence of inhibitor development in hemophilia a patients receiving recombinant factor viii therapy. materials and methods: this was an observational descriptive study. clotting factor...

The Survey of Effective Agents on Factor VIII and IX Inhibitors in Patients with Hemophilia A and B in Kermanshah Province

  Background: Hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors VIII (Hemophilia A) or IX (Hemophilia B) in plasma. We aimed to identify patients with  hemophilia in Kermanshah, Iran and assess the incidence of inhibitors in this population and its associated factors. Methods: This study was conducted on patients with hemophilia...

Antibodies to factor VIII. I. Variations in stability of antigen-antibody complexes in hemophilia A.

Human factor VIll-anti-factor VIII comThe extent of dissociation was measured plexes were formed in vitro in slight antiby the recovery of anti-factor VIII activity. gen excess, using plasma of hemophiliacs Increasing resistance of complexes towho were found to have antibodies neuwards dissociation was observed in the tralizing AHF activity. These complexes, plasma of the patients whose titer o...